The BSE benchmark Sensex fell 152.69 points or 0.31 per cent to 49,472.07 in early trade on January 22, tracking subdued Asian markets.
Likewise, the Nifty dropped 54.35 points or 0.37 per cent to 14,590.35 in opening trade.
On the Sensex chart, Axis Bank, Tech Mahindra, ONGC, Dr Reddy’s, Bajaj Finance and Sun Pharma were major laggards.
Bajaj Auto, Asian Paints, Mahindra and Mahindra, Maruti Suzuki and Reliance Industries were top gainers.
On January 21, the Sensex had dropped 167.36 points or 0.34 per cent to end at 49,624.76, and the Nifty had shed 54.35 points or 0.37 per cent to close at 14,590.35.
Intra-day, the 30-share BSE Sensex had touched the 50,000-level for the first time ever on Thursday on growth optimism and global cues but succumbed to profit-booking in fag-end trade.
Asian shares were trading broadly lower in late afternoon deals on Friday, a day after hitting record highs.
Foreign institutional investors remained net buyers in the capital market as they purchased shares worth Rs.1,614.66 crore on Thursday, according to exchange data.
The global oil benchmark Brent crude slipped 1.37 per cent to $55.40 per barrel.
